Related Experiment Video
Updated: Jun 2, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Systemic treatment of advanced malignant-melanoma (review)
Abstract:
The medical treatment of advanced or metastatic malignant melanoma is still controversial and no standard systemic therapy can be claimed. The selection of patients is an important factor to evaluate the results from clinical trials. Among the chemotherapeutic agents dacarbazine is still the most widely employed drug, because of the scarce evidence of better survival from multidrugs combinations. Fotoemustine is one of the most promising new drugs showing non cross resistance with dacarbazine and effectiveness on brain metastases. Interleukin-2 and interferon are active, but no more than single chemo-therapeutic agents, despite the higher cost. However, ongoing trials are exploring the combination of immuno- and chemotherapeutic agents with some very good preliminary results. In fact, for the above reported reasons, a patient with advanced malignant melanoma should be treated according to research protocols in specialized centers until an effective standard approach will be developed.
Related Concept Videos
Tumor Immunotherapy
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Treatment Resistant Cancers
Treatment Resistent Cancers
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

