Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Treatment Resistent Cancers

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Measurement of O-6-methylguanine-DNA methyltransferase activity using oligonucleotides and restriction enzyme in human brain tumors.

International journal of oncology·2011

Same author

Cerebral white matter lesions may be partially reversible in patients with carotid artery stenosis.

AJNR. American journal of neuroradiology·2010

Same author

MR imaging of ventral thalamic nuclei.

AJNR. American journal of neuroradiology·2009

Same author

Incidental acute infarcts identified on diffusion-weighted images: a university hospital-based study.

AJNR. American journal of neuroradiology·2008

Same author

Multitensor tractography enables better depiction of motor pathways: initial clinical experience using diffusion-weighted MR imaging with standard b-value.

AJNR. American journal of neuroradiology·2007

Same author

Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation.

Acta neurologica Scandinavica·2007

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Malignant gliomas treated with split course radiotherapy plus chemotherapy.

K Mineura¹, K Watanabe, M Kowada

¹AKITA UNIV HOSP,DEPT RADIOL,AKITA,JAPAN.

International Journal of Oncology

|May 17, 2011

Summary

Split course radiotherapy combined with chemotherapy did not significantly improve survival for malignant gliomas compared to continuous radiotherapy. Survival outcomes for malignant astrocytoma and glioblastoma multiforme remain similar across treatment groups.

More Related Videos

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Related Experiment Videos

Last Updated: Jun 2, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Area of Science:

Neuro-oncology
Radiation Oncology
Medical Oncology

Background:

Malignant gliomas, including astrocytoma and glioblastoma multiforme, are aggressive brain tumors.
Optimal treatment strategies for malignant gliomas are continuously being investigated to improve patient survival.

Purpose of the Study:

To evaluate the efficacy of combined modality treatment using split-course radiotherapy (sRT) with nimustine hydrochloride (ACNU) and tegafur (FT) in adult patients with supratentorial malignant gliomas.
To compare the survival outcomes of this combined modality approach against historical controls receiving continuous-course radiotherapy (cRT) with or without chemotherapy.

Main Methods:

A cohort of 25 adult patients with histologically verified supratentorial malignant gliomas received postoperative sRT (30 Gy whole brain followed by a 50-60 Gy boost) combined with ACNU and FT.
Treatment outcomes were compared to historical control groups who received cRT alone or with chemotherapy prior to 1979 and after 1986.
Kaplan-Meier survival analysis and the generalized Wilcoxon test were employed for statistical comparison.

Main Results:

The median survival time (MST) for patients receiving sRT plus chemotherapy was 18 months.
Historical control groups showed MSTs of 12 months for cRT alone and 13 months for cRT plus chemotherapy.
No statistically significant differences in survival curves were observed between the sRT plus chemotherapy group and the cRT control groups.

Conclusions:

The combined modality treatment of split-course radiotherapy with nimustine hydrochloride and tegafur did not demonstrate a significant survival benefit over continuous-course radiotherapy for supratentorial malignant gliomas.
Patient age, Karnofsky performance status, and tumor histology were identified as significant prognostic factors influencing survival in malignant glioma patients.