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P-glycoprotein - low constitutional expression does not correlate with treatment failure in follicular lymphomas
L Seymour1, M Davidgepitts, D Lewis
1UNIV WITWATERSRAND,SCH MED,DEPT MED,DIV CLIN HAEMATOL & MED ONCOL,YORK RD,JOHANNESBURG 2193,SOUTH AFRICA. JOHANNESBURG HOSP,JOHANNESBURG 2193,SOUTH AFRICA.
Abstract:
Tissue P-glycoprotein immunostaining was performed in seventy one patients with follicular large, mixed, or small cell non-Hodgkin's lymphomas. Only six patients (8.5%) demonstrated positive immunostaining for P-glycoprotein. All patients had complete and durable responses to initial therapy. P-glycoprotein (MDR) fails to predict for primary drug resistance in follicular lymphomas and is constitutionally expressed in only a few follicular lymphomas at present.
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