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Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing

John Huntriss1, Kathryn Woodfine, Joanna E Huddleston

  • 1Division of Reproduction and Early Development, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, The LIGHT Laboratories, Clarendon Way, Leeds, United Kingdom. j.huntriss@leeds.ac.uk

Fertility and Sterility
|May 18, 2011
PubMed

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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...