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Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: Jun 2, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Lymphatic vascular morphogenesis in development, physiology, and disease.

Stefan Schulte-Merker1, Amélie Sabine, Tatiana V Petrova

  • 1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, and University Medical Centre, 3584 CT Utrecht, Netherlands.

The Journal of Cell Biology
|May 18, 2011
PubMed
Summary

The lymphatic vasculature is vital for fluid balance, fat absorption, and immunity. Understanding its development and diseases like lymphedema is key to creating new therapies for human conditions.

Related Experiment Videos

Last Updated: Jun 2, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

  • Vascular Biology
  • Developmental Biology
  • Immunology

Background:

  • The lymphatic vasculature is a critical component of the circulatory system.
  • It plays essential roles in fluid homeostasis, lipid absorption, and immune surveillance.
  • Dysfunctional lymphatic vessels are implicated in diseases such as cancer metastasis and chronic inflammation.

Purpose of the Study:

  • To review current knowledge on lymphatic vessel development and pathology.
  • To highlight the significance of recent research in understanding lymphatic morphogenesis.
  • To emphasize the need for translating this knowledge into therapeutic strategies.

Main Methods:

  • Review of studies on embryonic development.
  • Analysis of genetically engineered animal models.
  • Examination of human lymphedema genetic data.

Main Results:

  • Advances in understanding the mechanisms regulating lymphatic vessel formation.
  • Insights into the molecular basis of lymphatic disorders.
  • Identification of key pathways involved in normal and pathological lymphatic development.

Conclusions:

  • Knowledge of lymphatic vasculature development and disease mechanisms has significantly advanced.
  • This understanding provides a foundation for developing novel therapeutic interventions.
  • Targeting lymphatic pathways offers potential for treating various human diseases.