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Updated: Jun 1, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
(E)-3-Bromo-N'-(4-methoxy-benzyl-idene)benzohydrazide methanol solvate.
1Department of Chemistry, Ankang University, Ankang Shanxi 725000, People's Republic of China.
Researchers synthesized a novel compound using 4-methoxy-benzaldehyde and 3-bromo-benzohydrazide. Structural analysis revealed specific molecular configurations and hydrogen bonding, impacting crystal packing.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Benzohydrazide derivatives are important in medicinal chemistry.
- Understanding molecular interactions is key to designing new materials.
Purpose of the Study:
- To synthesize and characterize a novel benzohydrazide derivative.
- To investigate the crystal structure and intermolecular interactions.
Main Methods:
- Chemical synthesis involving condensation reaction.
- Single-crystal X-ray diffraction for structural determination.
Main Results:
- Successful synthesis of C(15)H(13)BrN(2)O(2)·CH(3)OH.
- The benzohydrazide moiety exhibits an E configuration.
- A dihedral angle of 4.0(2)° between benzene rings was observed.
- A chain structure along the b-axis formed via hydrogen bonding.
Conclusions:
- The study provides insights into the synthesis and structural properties of a new benzohydrazide compound.
- Hydrogen bonding plays a crucial role in the crystal packing and molecular assembly.
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Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.

