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Updated: Jun 1, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-Methyl-3-phenyl-quinoxalin-2(1H)-one.
Summary
The study reveals twisted phenyl groups in C(15)H(12)N(2)O molecules, impacting their structure relative to the quinoxaline core.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Quinoxaline derivatives are important in medicinal chemistry and materials science.
- Understanding the three-dimensional structure of organic compounds is crucial for predicting their properties.
Purpose of the Study:
- To determine the crystal structure of the title compound, C(15)H(12)N(2)O.
- To analyze the spatial arrangement of the phenyl substituents relative to the quinoxaline core.
Main Methods:
- Single-crystal X-ray diffraction analysis was employed.
- The crystal structure was solved and refined.
Main Results:
- The title compound, C(15)H(12)N(2)O, crystallizes with two independent molecules in the asymmetric unit.
- In both molecules, the phenyl substituents exhibit significant twisting relative to the quinoxaline ring system.
- Specific dihedral angles were measured at 19.3(1)° and 30.4(1)°.
Conclusions:
- The observed twisted conformations are a key structural feature of this quinoxaline derivative.
- This structural information is vital for further research into the compound's chemical and physical properties.
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