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Updated: Jun 1, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
2-(4-Fluoro-phen-yl)-3-(4-pyrid-yl)pyrido[2,3-b]pyrazine
Abstract:
In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine system makes dihedral angles of 45.51 (7) and 44.75 (7)° with the attached 4-fluoro-phenyl ring and the pyridine ring, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 54.54 (8)° with the pyridine ring. The pyridine ring part of the pyridopyrazine ring and the pyrazine ring of two c-glide-plane-related mol-ecules form π-π inter-actions. The angle between the planes is 2.09 (7)° and the distance between the centroids is 3.557 (1)Å.
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