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Updated: Aug 7, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Specificity of cell surface virus receptors on radiation leukemia virus and radiation-induced thymic lymphomas

M S McGrath, A Decléve, M Lieberman

    Journal of Virology
    |December 1, 1978
    PubMed

    Insights

    Researchers identified specific murine leukemic virus (MuLV) receptors on thymic lymphoma cells. This receptor-ligand interaction is crucial for leukemic transformation, binding only leukemogenic retroviruses.

    Area of Science:

    • Oncology
    • Virology
    • Immunology

    Background:

    • Murine leukemic viruses (MuLV) are implicated in thymic lymphoma development.
    • Understanding virus-receptor interactions is key to elucidating leukemogenesis.

    Purpose of the Study:

    • To develop a system for analyzing MuLV receptors on thymic lymphoma cells.
    • To investigate the specificity of MuLV binding to lymphoma cells.

    Main Methods:

    • Utilized fluorescence-activated cell sorting (FACS) to analyze MuLV binding.
    • Employed fluoresceinated and rhodaminated MuLV for binding assays.
    • Performed competitive binding studies with homologous and heterologous MuLV strains.

    Main Results:

    • MuLV binding to thymic lymphoma cells exhibited saturation kinetics and specificity.
    • Lymphoma cells preferentially bound the specific MuLV that induced them.
    • Normal thymocytes showed minimal binding compared to lymphoma cells.
    • Leukemogenic MuLV isolates were specifically bound, while non-leukemogenic MuLV were not.

    Conclusions:

    • The study demonstrates a specific receptor-ligand interaction between leukemogenic MuLV and thymic lymphoma cells.
    • This interaction plays a significant role in the process of leukemic transformation.
    • The developed system provides a tool for further research into retroviral leukemogenesis.

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