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[Biodistribution of new polynitroxides using electron paramagnetic resonance]
M E Brik1, J M Pechine, J Courtieu
1Laboratoire de Chimie Structurale Organique, Université Paris-Sud, Orsay.
Journal De Radiologie
|February 1, 1990
Abstract:
The most important paramagnetic contrast agents used in Nuclear Magnetic Resonance Imaging are limited to a few metal complexes such Gd-DTPA or stable free radicals such as nitroxides simply functionalized. We studied the biodistribution of new polynitroxides agents by Electronic Paramagnetic Resonance in Sprague Dawley rats. Three of the six different polynitroxides agents studied, showed an interesting and selective localisation in the lungs, heart and liver.