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Updated: Jun 1, 2026
09:35
Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
N-Cyclo-hexyl-N-ethyl-benzene-sulfonamide
Summary
Researchers synthesized a novel sulfur-containing compound, C(14)H(21)NO(2)S, via N-methylation. This molecule is a potential precursor for biologically active heterocyclic compounds, with detailed structural analysis revealing two independent molecules in the asymmetric unit.
Area of Science:
- Organic Chemistry
- Crystallography
- Medicinal Chemistry
Background:
- Sulfur-containing heterocyclic compounds exhibit diverse biological activities.
- Precursors for novel bioactive molecules are crucial in drug discovery.
- N-methylation is a common synthetic route to modify amine functionalities.
Purpose of the Study:
- To synthesize and characterize a novel N-methylated cyclohexylamine sulfonamide derivative.
- To investigate the potential of this compound as a precursor for sulfur-containing heterocycles.
- To elucidate the crystal structure and molecular conformation.
Main Methods:
- N-methylation of cyclohexylamine sulfonamide using ethyl iodide.
- Single-crystal X-ray diffraction for structural determination.
- Analysis of molecular geometry, including dihedral angles between ring systems.
Main Results:
- The title compound, C(14)H(21)NO(2)S, was successfully synthesized.
- The crystal structure revealed two independent molecules in the asymmetric unit.
- Dihedral angles between the phenyl and cyclohexyl rings were determined to be 40.29(11)° and 37.91(13)°.
Conclusions:
- The synthesized compound serves as a valuable building block for sulfur-containing heterocyclic chemistry.
- The structural data provides insights into the conformational preferences of the molecule.
- Further exploration of its derivatives may lead to new therapeutic agents.
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