Related Experiment Video
Updated: Jun 1, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
4-Benzene-sulfonamido-benzoic acid
This study details the crystal structure of a sulfonamide compound, C(13)H(11)NO(4)S. Molecular analysis reveals specific dihedral and inter-ring angles, with crystal stabilization through hydrogen bonding.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Sulfonamide compounds are crucial in medicinal chemistry and materials science.
- Understanding molecular geometry and intermolecular interactions is key to predicting material properties.
Purpose of the Study:
- To elucidate the crystal structure and intermolecular interactions of a specific sulfonamide compound (C(13)H(11)NO(4)S).
- To provide detailed geometric parameters of the molecule and its packing in the solid state.
Main Methods:
- Single-crystal X-ray diffraction was used to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, dihedral angles, and intermolecular interactions (hydrogen bonds).
Main Results:
- The dihedral angle between the benzene ring and the carboxyl group is 6.7(4)°.
- The two aromatic rings are inclined at 45.36(15)° to each other.
- The crystal structure is stabilized by intermolecular N-H⋯O, O-H⋯O, and C-H⋯O hydrogen bonds.
Conclusions:
- The study provides a precise description of the molecular conformation and crystal packing of the title sulfonamide.
- The identified hydrogen bonding network is critical for the stability of the observed crystal structure.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
09:34Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Related Concept Videos
Electrophilic Aromatic Substitution: Sulfonation of Benzene
NMR Spectroscopy of Benzene Derivatives
Electrophilic Aromatic Substitution: Nitration of Benzene
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Nomenclature of Aromatic Compounds with a Single Substituent