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Basicity of Heterocyclic Aromatic Amines

Basicity of Heterocyclic Aromatic Amines

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Related Experiment Video

Updated: Jun 1, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

Published on: June 10, 2021

2-Pyridone: monoclinic polymorph.

Hadi D Arman, Pavel Poplaukhin, Edward R T Tiekink

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This study identifies a new monoclinic polymorph of 2-pyridone. Unlike the orthorhombic form, this crystal structure features 2-pyridone molecules forming dimers through amide synthons.

Area of Science:

Crystallography
Solid-state chemistry

Background:

2-pyridone exists in multiple crystalline forms.
Previous studies reported an orthorhombic polymorph with helical chains.

Purpose of the Study:

To characterize a novel monoclinic polymorph of 2-pyridone.
To elucidate the supramolecular assembly in this new crystal form.

Main Methods:

Single-crystal X-ray diffraction analysis.
Comparison with previously reported crystal structures.

Main Results:

The asymmetric unit contains two independent, virtually identical 2-pyridone molecules.
A monoclinic polymorph (space group C2/c) was identified.
Supramolecular dimers are formed via eight-membered {⋯HNC(O)}(2) amide synthons.

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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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This contrasts with the helical chains observed in the orthorhombic form.

Conclusions:

The discovery of a new monoclinic polymorph of 2-pyridone expands the understanding of its solid-state behavior.
The distinct supramolecular arrangement highlights polymorphism-dependent structural diversity.