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Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
7-Chloro-4-[(E)-(3-chloro-benzyl-idene)hydrazinyl]-1λ-quinolinium 3-chloro-benzoate
Abstract:
The title salt, C(16)H(12)Cl(2)N(3) (+)·C(7)H(4)ClO(2) (-), features a non-planar cation, the dihedral angle between the quinolinium and benzene residues being 18.98 (10)°. The cation adopts an E conformation about the C-N bond, and the amine group is oriented towards the quinolinium residue. In the crystal, N-H⋯O hydrogen bonds link two cations with two anions, forming a 20-membered {⋯OCO⋯HNC(3)NH}(2) synthon. The dimeric units are connected into a linear supra-molecular chain along [100] via π-π inter-actions [centroid-centroid distance = 3.5625 (13) Å].
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Alkyl Halides
Alkyl halides are halogen-substituted alkanes wherein one or more hydrogen atoms of an alkane is replaced by a halogen atom such as fluorine, chlorine, bromine, or iodine. The carbon atom in an alkyl halide is bonded to the halogen atom, which is sp3-hybridized and exhibits a tetrahedral shape.
Unlike alkyl halides, compounds in which a halogen atom is bonded to an sp2 -hybridized carbon atom of a carbon-carbon double bond (C=C) are called vinyl halides. Whereas aryl...
