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Updated: Jun 1, 2026
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Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
N'-(2,3-Dimethoxy-benzyl-idene)-2-hydr-oxy-3-methyl-benzohydrazide
1Department of Chemistry and Life Science, Chuzhou University, Chuzhou, Anhui 239000, People's Republic of China.
Summary
This study characterizes a novel organic compound, C(17)H(18)N(2)O(4), detailing its molecular structure and intermolecular interactions. The research reveals specific hydrogen bonding patterns and crystal packing crucial for understanding its solid-state properties.
Area of Science:
- Crystallography
- Organic Chemistry
- Supramolecular Chemistry
Background:
- Understanding the solid-state structure of organic molecules is essential for predicting their physical and chemical properties.
- Hydrogen bonding plays a critical role in molecular self-assembly and crystal engineering.
- The specific arrangement of molecules in a crystal lattice influences macroscopic behavior.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(17)H(18)N(2)O(4).
- To investigate the intramolecular and intermolecular interactions within the crystal.
- To describe the hydrogen bonding network and its impact on crystal packing.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and dihedral angles provided detailed structural information.
- Hydrogen bond analysis was performed to identify and characterize intra- and intermolecular interactions.
Main Results:
- The compound C(17)H(18)N(2)O(4) exhibits an E configuration around the C=N bond.
- A significant dihedral angle of 6.0(2)° was observed between the two benzene rings.
- An intramolecular O-H⋯O hydrogen bond forms a stable S(6) ring, while intermolecular N-H⋯O hydrogen bonds create C(4) chains along the c axis.
Conclusions:
- The crystal structure of C(17)H(18)N(2)O(4) is characterized by specific dihedral angles and E-configuration.
- Intramolecular hydrogen bonding contributes to the molecule's conformation.
- Intermolecular hydrogen bonding dictates the formation of one-dimensional chains in the crystal lattice, providing insights into supramolecular assembly.
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