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Updated: Jun 1, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
3-[2-(3-Methyl-quinoxalin-2-yl-oxy)eth-yl]-1,3-oxazolidin-2-one
Summary
Researchers detailed the crystal structure of a novel isomer formed from 3-methyl-quinoxalin-2-one and bis-(2-chloro-ethyl)amine hydrochloride. This isomer features linked oxazolidine and quinoxaline rings, differing in oxazolidine group positioning.
Area of Science:
- Organic Chemistry
- Crystallography
- Medicinal Chemistry
Background:
- Two isomers were synthesized from the reaction of 3-methyl-quinoxalin-2-one and bis-(2-chloro-ethyl)amine hydrochloride.
- The crystal structure of one isomer was previously elucidated.
- This study focuses on the structural characterization of the second isomer.
Purpose of the Study:
- To determine the crystal structure of the second isomer.
- To elucidate the structural differences between the two isomers.
- To characterize the novel compound C(14)H(15)N(3)O(3).
Main Methods:
- Single-crystal X-ray diffraction analysis.
- Structural comparison with the previously reported isomer.
- Analysis of molecular geometry and conformation.
Main Results:
- The crystal structure of the second isomer was determined.
- The compound features interconnected oxazolidine and quinoxaline ring systems via an ethoxy linkage.
- A significant dihedral angle of 41.63(8)° was observed between the ring systems.
Conclusions:
- The distinct structural arrangement of the oxazolidine group relative to the quinoxaline core was confirmed.
- The study contributes to understanding the structure-activity relationships of quinoxaline derivatives.
- The findings provide valuable crystallographic data for this class of organic compounds.
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