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Updated: Jun 1, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N'-[1-(2-Amino-phen-yl)ethyl-idene]benzo-hydrazide
1Faculty of Science, Department of Chemistry, Banaras Hindu University, Varanasi, U. P. 221 005, India.
Summary
This study synthesized a novel organic compound, C(15)H(15)N(3)O, via condensation reaction. Structural analysis revealed specific hydrogen bonding patterns and a non-planar molecular conformation due to steric interactions.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure
Background:
- Condensation reactions are fundamental in organic synthesis.
- Understanding molecular conformation and hydrogen bonding is crucial for predicting chemical properties.
Purpose of the Study:
- To synthesize and characterize a novel organic compound, C(15)H(15)N(3)O.
- To elucidate the molecular structure, including configuration, hydrogen bonding, and conformation.
Main Methods:
- Synthesis via condensation reaction of o-amino-acetophenone and benzoyl hydrazine.
- X-ray crystallography to determine the solid-state structure.
- Analysis of intra- and intermolecular hydrogen bonding.
Main Results:
- Successful synthesis of the target compound C(15)H(15)N(3)O.
- The molecule exhibits an E configuration around the C=N bond.
- Intra- and intermolecular hydrogen bonds (N-H⋯N and N-H⋯O) were identified, forming dimers in the crystal.
- A twisted, non-planar molecular geometry was observed due to steric hindrance.
Conclusions:
- The study successfully synthesized and characterized a new organic compound.
- The detailed structural analysis provides insights into the role of hydrogen bonding and steric effects in molecular conformation.
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