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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
4-(2-Oxa-6-aza-spiro-[3.3]hept-6-yl)-benzo-nitrile
1Department of Pharmacy, West China Hospital of Sichuan University, Chengdu 610041, People's Republic of China.
Abstract:
In the title compound, C(12)H(12)N(2)O, the azetidine ring (r.m.s. deviation = 0.021 Å) and the oxetane ring (r.m.s. deviation = 0.014 Å) are nearly perpendicular to each other [dihedral angle = 89.7 (1)°]. The azetidine ring is twisted out of the plane of the benzene ring by 18.3 (1)°. In the crystal structure, mol-ecules are linked to form chains along the c axis by C-H⋯O hydrogen bonds.
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