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Updated: Jun 1, 2026
04:38
Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
1-Tetra-decyl-indoline-2,3-dione.
Summary
This study analyzes N-alkyl isatin, revealing a planar isatin core. The long tetra-decyl chain adopts a specific anti-periplanar conformation, offering insights into molecular structure.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure Analysis
Background:
- Isatin derivatives are significant in medicinal chemistry and materials science.
- Understanding the conformational preferences of N-alkyl substituents is crucial for predicting molecular properties and interactions.
Purpose of the Study:
- To elucidate the three-dimensional molecular structure of a specific N-alkyl isatin derivative.
- To investigate the conformational characteristics of the isatin core and its N-alkyl chain.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed on N-alkyl isatin (C(22)H(33)NO(2)).
- Analysis of atomic coordinates and bond parameters to determine molecular geometry.
Main Results:
- The isatin moiety within the N-alkyl isatin molecule was found to be planar, with a root-mean-square deviation of 0.03 Å.
- The tetra-decyl substituent exhibited a fully extended conformation, with all torsion angles adopting an anti-periplanar arrangement.
Conclusions:
- The planar nature of the isatin core is maintained in this N-alkyl derivative.
- The extended anti-periplanar conformation of the long alkyl chain suggests specific packing or intermolecular interactions in the solid state.
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