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Updated: Jun 1, 2026
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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2,2,2-Trifluoro-N-(isoquinolin-5-ylmeth-yl)acetamide
Alan R Kennedy1, Abedawn I Khalaf, Colin J Suckling
1Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland.
Abstract:
The mol-ecular structure of the title compound at 123 K, C(12)H(9)F(3)N(2)O, presents a rotationally disordered CF(3) group. Hydrogen bonds between the amide NH group and the N atom of the isoquinoline form a chain in the b-axis direction. The packed structure forms alternate layers of isoquinoline and amide groups parallel to the ab plane.
