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Updated: Jun 1, 2026

11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
7-Chloro-4-[(E)-N'-(4-fluoro-benzyl-idene)hydrazin-yl]quinoline monohydrate
Abstract:
The mol-ecule of the title hydrate, C(16)H(11)ClFN(3)·H(2)O, is slightly twisted, as indicated by the dihedral angle of 9.55 (10)° formed between the quinoline ring system and the benzene ring. The conformation about the C=N double bond is E, and the amine-H atom is oriented towards the quinoline residue. In the crystal structure, the water mol-ecule accepts an N-H⋯O and makes two O-H⋯N(quinoline) hydrogen bonds, generating a two-dimensional array in the ab plane, which is further stabilized by C-H⋯O inter-actions. The most significant contacts between layers are of the type C-H⋯F.
