Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic antagonists are called...
Esters to β-Ketoesters: Claisen Condensation Overview01:24

Esters to β-Ketoesters: Claisen Condensation Overview

Regular Claisen condensation is a base-promoted reaction involving identical esters with two α hydrogens, condensing to produce β-ketoesters. It is a nucleophilic acyl substitution reaction wherein one of the ester molecules, upon deprotonation by the base, forms a nucleophilic enolate ion, while the other molecule serves as an electrophile.
Naming Enantiomers02:21

Naming Enantiomers

The naming of enantiomers employs the Cahn–Ingold–Prelog rules that involve assigning priorities to different substituent groups at a chiral center. Each enantiomer, being a distinct molecule, is assigned a unique name by the Cahn–Ingold–Prelog (CIP) rules, also called the R–S system. The prefix R- or S- attached to the chiral centers in an enantiomer is dependent on the spatial arrangement of the four substituents on the chiral center. The R–S system essentially comprises three steps:...
Cholinergic Antagonists: Pharmacokinetics01:24

Cholinergic Antagonists: Pharmacokinetics

Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and the conjunctiva.
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bis(ferrocenecarbaldehyde 4-methyl-thio-semicarbazonato-κN,S)zinc(II) methanol solvate.

Acta crystallographica. Section E, Structure reports online·2011
Same author

Poly[[diaqua-(3-carb-oxy-5-nitro-ben-zo-ato)(μ-5-nitro-benzene-1,3-dicarboxyl-ato)neodymium(III)] 2.5-hydrate].

Acta crystallographica. Section E, Structure reports online·2011
Same author

2-((E)-{2-[(E)-2,3-Dihydroxy-benzyl-ideneamino]-5-methyl-phen-yl}iminiometh-yl)-6-hydroxy-phenolate.

Acta crystallographica. Section E, Structure reports online·2011
Same author

Ethyl 4-butyl-amino-3-nitro-benzoate.

Acta crystallographica. Section E, Structure reports online·2011
Same author

(1Z)-1-(2,4-Dichloro-phen-yl)ethan-1-one semicarbazone.

Acta crystallographica. Section E, Structure reports online·2011
Same author

4-[(4-Fluoro-benzyl-idene)amino]-3-[1-(4-isobutyl-phen-yl)eth-yl]-1H-1,2,4-triazole-5(4H)-thione.

Acta crystallographica. Section E, Structure reports online·2011

Related Experiment Video

Updated: Jun 1, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
09:26

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

3β-Chloro-cholest-5-en-7-one.

Mohd Shaheen Khan, Othman Sulaiman, Rokiah Hashim

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    This study details the crystal structure of a chlorinated steroid derivative, revealing its molecular conformation and antiparallel layer arrangement. The findings illuminate the three-dimensional network formed by C-H⋯O hydrogen bonds in this steroid compound.

    More Related Videos

    Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
    13:38

    Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

    Published on: April 11, 2017

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
    14:22

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

    Published on: April 15, 2013

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
    09:26

    Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

    Published on: November 17, 2011

    Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
    13:38

    Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

    Published on: April 11, 2017

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
    14:22

    Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

    Published on: April 15, 2013

    Area of Science:

    • Steroid chemistry
    • Crystallography
    • Organic chemistry

    Background:

    • Steroid derivatives are crucial in biochemistry and medicine.
    • Understanding their solid-state structure informs their properties and interactions.
    • The title compound is a novel chlorinated steroid.

    Purpose of the Study:

    • To elucidate the crystal structure and molecular conformation of the title chlorinated steroid derivative.
    • To analyze the intermolecular interactions and packing in the crystal lattice.
    • To provide insights into the structure-property relationships of steroid compounds.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the three-dimensional structure.
    • Conformational analysis of the fused-ring system and the alkyl side chain was performed.
    • Analysis of intermolecular forces, specifically C-H⋯O hydrogen bonds, was conducted.

    Main Results:

    • The steroid derivative exhibits a saturated fused-ring framework with specific ring conformations (A/C: chair, B/D: half-chair).
    • The cholesterol side chain is fully extended, with terminal methyl groups in a gauche, trans conformation.
    • Crystal packing reveals antiparallel alignment of molecules into layers, interconnected by C-H⋯O hydrogen bonds forming a 3D network.

    Conclusions:

    • The detailed crystal structure provides a molecular-level understanding of this chlorinated steroid.
    • The observed packing and hydrogen bonding network are key features influencing the compound's solid-state properties.
    • This structural data serves as a foundation for further research into steroid derivative applications.