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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-(2,5-Dimethyl-phen-yl)-2-methyl-benzamide
This study details the crystal structure of a C16H17NO compound, revealing nearly coplanar aromatic rings and amide group orientations. Molecules form chains via intermolecular hydrogen bonds in the crystal lattice.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Understanding molecular arrangements in crystals is crucial for predicting material properties.
- The specific compound C16H17NO's structural characteristics were previously unexamined.
Purpose of the Study:
- To elucidate the three-dimensional molecular structure of the title compound C16H17NO.
- To analyze the spatial arrangement of aromatic rings and the amide group.
- To investigate intermolecular interactions within the crystal.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of bond lengths, bond angles, and dihedral angles provided detailed structural insights.
- Identification of intermolecular hydrogen bonding patterns was performed.
Main Results:
- The two aromatic rings in C16H17NO exhibit near-coplanarity with a dihedral angle of 1.9(2)°.
- The amide group displays dihedral angles of 48.0(3)° and 48.6(3)° with the substituted phenyl rings.
- Intermolecular N-H⋯O hydrogen bonds were observed, forming chains along the crystal's a axis.
Conclusions:
- The crystal structure of C16H17NO is characterized by specific dihedral angles between its aromatic and amide moieties.
- Hydrogen bonding plays a significant role in organizing the molecular packing in the solid state.
- These findings contribute to the understanding of structure-property relationships in organic crystalline materials.
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