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Updated: Jun 1, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2,2,2-Tribromo-N-(4-methyl-phen-yl)acetamide
Summary
This study reveals two distinct molecular orientations in the crystal structure of a tribromo compound. Intermolecular hydrogen bonds link these molecules into chains, influencing crystal packing.
Area of Science:
- Crystallography
- Organic Chemistry
- Chemical Physics
Background:
- Understanding molecular arrangements in crystals is crucial for predicting material properties.
- The specific compound C(9)H(8)Br(3)NO presents an interesting case due to its tribromo substitution.
- Previous studies on similar halogenated organic compounds provide context for this investigation.
Purpose of the Study:
- To elucidate the crystal structure of C(9)H(8)Br(3)NO.
- To analyze the intermolecular interactions and packing in the crystal lattice.
- To investigate the influence of the tribromo group on molecular conformation and crystal assembly.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of the crystal structure included identifying hydrogen bonding networks.
- Molecular geometry and conformation were examined.
Main Results:
- The asymmetric unit contains two independent molecules with differing tribromo group orientations.
- A weak intramolecular N-H⋯Br hydrogen bond was identified within each molecule.
- Intermolecular N-H⋯O hydrogen bonds link the molecules into chains along the b-axis.
Conclusions:
- The crystal structure of C(9)H(8)Br(3)NO is characterized by two distinct molecular conformations.
- Intramolecular and intermolecular hydrogen bonding play significant roles in stabilizing the crystal structure.
- The observed packing arrangement provides insights into the solid-state behavior of this halogenated organic compound.
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Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary amide...
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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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