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Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

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Bruceine a.

Xue-Huan Feng¹, Yan-Ning Zhang, Wei-Zhi He

¹State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This summary is machine-generated.

Bruceine A, a natural quassinoid from Brucea javanica, has a complex five-ring structure. Its molecular conformation and crystal structure are stabilized by specific hydrogen bonds.

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Area of Science:

Natural Product Chemistry
Organic Chemistry
Structural Biology

Background:

Brucea javanica fruits are a source of bioactive natural products.
Quassinoids are a class of terpenoids with diverse biological activities.
Understanding the structure of natural compounds is crucial for their application.

Purpose of the Study:

To elucidate the detailed molecular structure of bruceine A.
To investigate the factors influencing bruceine A's molecular conformation.
To characterize the intermolecular interactions in the crystalline state of bruceine A.

Main Methods:

Isolation and purification of bruceine A from Brucea javanica.
Spectroscopic analysis (e.g., NMR, Mass Spectrometry) for structural determination.
X-ray crystallography for precise three-dimensional structure and intermolecular interactions.

Main Results:

The chemical formula of bruceine A was confirmed as C(26)H(34)O(11).
Bruceine A possesses a characteristic quassinoid skeleton with five fused rings.
Intramolecular hydrogen bonds dictate the molecular conformation, and intermolecular hydrogen bonds are observed in the crystal lattice.

Conclusions:

The detailed structure of bruceine A has been fully characterized.
Intramolecular hydrogen bonding plays a significant role in stabilizing the molecule's conformation.
Crystal structure analysis reveals intermolecular hydrogen bonding networks, providing insights into solid-state packing.