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Preparation and Reactions of Sulfides

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

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Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...

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Updated: Jun 1, 2026

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)

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Published on: June 28, 2011

N-(2,4-Dimethyl-phen-yl)succinimide.

B S Saraswathi, B Thimme Gowda, Sabine Foro

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

The crystal structure of a novel organic compound reveals a near-perpendicular arrangement between its benzene ring and imide group. Molecules self-assemble into unique zigzag chains within the crystal lattice.

Area of Science:

Crystallography
Organic Chemistry
Materials Science

Background:

Understanding molecular packing is crucial for predicting material properties.
The dihedral angle between aromatic and imide groups influences electronic and physical characteristics.
Crystal engineering aims to control supramolecular structures for desired functions.

Purpose of the Study:

To determine the precise three-dimensional structure of the title compound, C(12)H(13)NO(2).
To investigate the molecular conformation and intermolecular interactions within the crystal.
To describe the crystal packing arrangement.

Main Methods:

Single-crystal X-ray diffraction was employed to collect diffraction data.
The crystal structure was solved and refined using standard crystallographic software.

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Analysis of bond lengths, bond angles, and torsion angles provided conformational details.

Main Results:

The dihedral angle between the benzene ring and the imide segment was determined to be 85.7°.
A detailed analysis of intermolecular contacts was performed.
The crystal structure exhibits zigzag chains of molecules aligned parallel to the a axis.

Conclusions:

The compound adopts a specific conformation with a near-orthogonal orientation between the benzene and imide moieties.
The observed zigzag chain packing suggests potential for directional intermolecular interactions.
This structural information provides a foundation for further studies on the compound's physical and chemical properties.