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Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides

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Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.

Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

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Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme activation, sulfur...

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Nomenclature of Secondary and Tertiary Amines

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IUPAC Nomenclature of Aldehydes

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Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)

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Summary

This summary is machine-generated.

This study details the crystal structure of C(11)H(13)NO(3), revealing specific molecular conformations and intermolecular interactions. These interactions, including hydrogen bonds and C-H⋯π interactions, dictate the compound

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Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

Published on: January 3, 2018

Area of Science:

Crystallography
Molecular structure
Organic chemistry

Background:

Understanding molecular conformations is crucial for predicting chemical properties.
Intermolecular interactions influence crystal packing and material properties.

Purpose of the Study:

To elucidate the detailed crystal structure of the title compound, C(11)H(13)NO(3).
To analyze the specific conformations of amide and benzene ring substituents.
To identify and characterize intermolecular interactions within the crystal lattice.

Main Methods:

Single-crystal X-ray diffraction analysis.
Analysis of bond conformations (anti, syn).
Identification of hydrogen bonding (O-H⋯O, N-H⋯O) and C-H⋯π interactions.

Main Results:

The crystal structure of C(11)H(13)NO(3) was determined.
Anti conformations of N-H and C=O bonds and syn conformation of the amide H atom were observed.
Carboxylic acid inversion dimers and infinite chains formed via intermolecular hydrogen bonds were identified.
Intermolecular C-H⋯π interactions were also present.

Conclusions:

The crystal structure reveals specific conformational preferences within the molecule.
Intermolecular interactions play a significant role in the self-assembly of the molecules in the solid state.
The findings contribute to the understanding of structure-property relationships in organic crystalline materials.