N'-[(5-Methyl-furan-2-yl)methyl-ene]isonicotinohydrazide
1Microscale Science Institute, Weifang University, Weifang 261061, People's Republic of China.
Summary
Researchers synthesized a novel compound C(12)H(11)N(3)O(2) from isonicotinohydrazide and 5-methyl-furan-2-carbaldehyde. Crystal analysis revealed specific ring interactions and intermolecular forces stabilizing its structure.
Area of Science:
- Organic Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- Isonicotinohydrazide is a versatile precursor in organic synthesis.
- Furan derivatives are important heterocyclic compounds with diverse applications.
- Understanding molecular interactions is key to designing new materials.
Purpose of the Study:
- To synthesize and characterize a new chemical entity derived from isonicotinohydrazide and a furan derivative.
- To elucidate the three-dimensional structure and crystal packing of the synthesized compound.
- To investigate the nature of intermolecular interactions governing crystal formation.
Main Methods:
- Chemical synthesis involving the reaction of isonicotinohydrazide and 5-methyl-furan-2-carbaldehyde.
- Single-crystal X-ray diffraction to determine molecular and crystal structure.
- Analysis of bond angles, dihedral angles, and intermolecular interactions.
Main Results:
- The title compound, C(12)H(11)N(3)O(2), was successfully synthesized.
- X-ray crystallography revealed a dihedral angle of 46.90(9)° between the pyridine and furan rings.
- The crystal structure is stabilized by a bifurcated intermolecular N-H⋯(N,O) interaction.
Conclusions:
- The synthesis yielded a novel compound with potential applications in medicinal chemistry or materials science.
- The observed dihedral angle provides insight into the conformational preferences of the molecule.
- The bifurcated intermolecular interaction highlights a specific mode of crystal stabilization relevant to supramolecular chemistry.
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