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Source of urinary cyclic AMP in response to calcitonin and parathyroid hormone in the rat
A F Firek1, S Ramanathan, S M Suh
1Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822.
Research Communications in Chemical Pathology and Pharmacology
|January 1, 1990
Abstract:
Administration of calcitonin (CT) or parathyroid hormone (PTH) in rats, induced phosphaturia with a concomitant increase in urinary excretion of cyclic AMP. CT produced a rise in arterial cAMP and filtered cAMP, with no increase in urinary nephrogenous cAMP. PTH on the other hand, produced an elevation in urinary nephrogenous cAMP with no increase in arterial cAMP and filtered cAMP. These results indicate that the source of urinary cAMP after CT is non-renal, whereas after PTH it is renal in origin.