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Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-Benzoyl-3-(5-quinol-yl)thio-urea
Abstract:
The title compound, C(17)H(13)N(3)OS, was obtained by the reaction of benzoyl chloride, ammonium thio-cyanate and 5-amino-quinoline in the presence of polyethyl-eneglycol-400 (PEG-400) as a phase-transfer catalyst. The compound crystallized as discrete mol-ecules linked by N-H⋯N and C-H⋯N hydrogen bonds involving all the potential donors, generating sheets parallel to (100). An intramolecular N-H⋯O bond is also present.
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