Methyl N-(4-chlorophenyl)succinamate
Abstract:
In the structure of the title compound {systematic name: methyl 3-[(4-chloro-phen-yl)amino-carbon-yl]propionate}, C(11)H(12)ClNO(3), the conformations of the N-H and C=O bonds in the amide fragment are trans to each other and the conformations of the amide O atom and the carbonyl O atom of the ester fragment are also trans to the H atoms attached to the adjacent C atoms. Mol-ecules are linked into a centrosymmetric R(2) (2)(14) dimer by simple N-H⋯O inter-actions. Furthermore, a short intra-molecular C-H⋯O contact may stabilize the conformation adopted by the mol-ecule in the crystal.
Related Concept Videos
Preparation and Reactions of Sulfides
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between the...
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
2° Amines to N-Nitrosamines: Reaction with NaNO2


