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Related Concept Videos

Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Amines to Sulfonamides: The Hinsberg Test01:23

Amines to Sulfonamides: The Hinsberg Test

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Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)01:30

Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)

Nucleophilic substitution in aromatic compounds is feasible in substrates bearing strong electron-withdrawing substituents positioned ortho or para to the leaving group. The reaction proceeds via two steps: the addition of the nucleophile and the elimination of the leaving group.
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between the...
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

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Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.

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Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Methyl N-(4-chlorophenyl)succinamate.

B Thimme Gowda, Sabine Foro, B S Saraswathi

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This study details the crystal structure of methyl 3-[(4-chlorophenyl)amino-carbonyl]propionate. Molecules form dimers through hydrogen bonds, with intramolecular contacts potentially stabilizing the crystal conformation.

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    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Molecular Structure

    Background:

    • Understanding molecular conformation and intermolecular interactions is crucial in crystal engineering.
    • The specific arrangement of functional groups dictates crystal packing and properties.

    Purpose of the Study:

    • To elucidate the crystal structure and molecular conformation of methyl 3-[(4-chlorophenyl)amino-carbonyl]propionate.
    • To investigate the intermolecular interactions, specifically hydrogen bonding, that govern crystal assembly.
    • To identify any intramolecular interactions that contribute to conformational stability.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the three-dimensional structure.
    • Analysis of bond and torsion angles provided insights into molecular conformation.
    • Intermolecular and intramolecular contacts were identified and analyzed.

    Main Results:

    • The crystal structure reveals specific trans conformations for the amide and ester fragments.
    • Molecules self-assemble into centrosymmetric dimers via N-H⋯O hydrogen bonds.
    • A short intramolecular C-H⋯O contact was observed, potentially stabilizing the molecular conformation.

    Conclusions:

    • The crystal structure of methyl 3-[(4-chlorophenyl)amino-carbonyl]propionate is characterized by specific conformational preferences.
    • Hydrogen bonding plays a key role in the formation of dimeric units.
    • Intramolecular interactions may contribute to the overall stability of the observed crystal conformation.