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Acute infectious mononucleosis. CD30 (Ki-1) antigen expression and histologic correlations
S L Abbondanzo1, N Sato, S E Straus
1Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
American Journal of Clinical Pathology
|May 1, 1990
Summary
Acute infectious mononucleosis (AIM) lymph nodes can mimic lymphoma due to immunoblastic proliferation. This case highlights the importance of considering Ki-1-positive lymphoma in the differential diagnosis of AIM.
Area of Science:
- Pathology
- Immunology
- Oncology
Background:
- Lymph nodes in acute infectious mononucleosis (AIM) exhibit paracortical expansion and immunoblastic proliferation.
- These features, along with Reed-Sternberg-like cells, can resemble non-Hodgkin's lymphoma or Hodgkin's disease.
- Ki-1-positive lymphoma (large cell anaplastic lymphoma) shares features with AIM, necessitating its consideration in differential diagnoses.