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Updated: Jun 1, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
(E)-N'-[1-(4-Hydroxy-phen-yl)ethyl-idene]-2-(quinolin-8-yl-oxy)acetohydrazide methanol solvate
1College of Biological and Chemical Engineering, Jiaxing University, Jiaxing 314001, People's Republic of China.
Summary
This study details the crystal structure of a C(19)H(17)N(3)O(3)·CH(4)O compound. It reveals specific hydrogen bonding patterns and molecular arrangements in the solid state, including inversion dimers and solvent interactions.
Area of Science:
- Crystallography
- Supramolecular Chemistry
- Organic Chemistry
Background:
- Understanding the three-dimensional arrangement of molecules in crystals is crucial for predicting material properties.
- Hydrogen bonding plays a significant role in molecular self-assembly and the formation of ordered structures.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(19)H(17)N(3)O(3)·CH(4)O.
- To analyze the intermolecular interactions, specifically hydrogen bonding, that govern the compound's solid-state architecture.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and intermolecular distances was performed.
Main Results:
- The crystal structure reveals a dihedral angle of 75.5(2)° between the benzene and quinoline ring systems.
- Acetohydrazide molecules form inversion dimers through intermolecular O-H⋯O hydrogen bonds.
- Methanol solvent molecules are incorporated, forming hydrogen bonds with the acetohydrazide moiety via N-H⋯O and bifurcated O-H⋯(N,O) interactions.
Conclusions:
- The study provides detailed insights into the supramolecular assembly of the title compound in the solid state.
- The identified hydrogen bonding network highlights the directional nature of intermolecular forces in crystal engineering.
- The findings contribute to the understanding of structure-property relationships in organic crystalline materials.
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