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Updated: Jun 1, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N-(2,3-Dimethyl-phen-yl)-2,2,2-trimethyl-acetamide
Summary
This study reveals the anti-conformation of the N-H bond relative to the C=O bond and methyl groups in a specific organic compound. Molecules form chains via intermolecular hydrogen bonds in the crystal structure.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure
Background:
- Understanding molecular conformation is crucial in organic chemistry.
- Intermolecular forces dictate crystal packing and material properties.
Purpose of the Study:
- To elucidate the conformational preferences of the N-H bond in C(13)H(19)NO.
- To characterize the crystal structure and intermolecular interactions of the title compound.
Main Methods:
- Single-crystal X-ray diffraction analysis was employed.
- Conformational analysis of the N-H and C=O bonds was performed.
- Hydrogen bonding networks in the crystal lattice were identified.
Main Results:
- The N-H bond was found to be anti to the C=O bond.
- The N-H bond exhibited an anti-relationship with both 2- and 3-methyl substituents on the aromatic ring.
- Intermolecular N-H⋯O hydrogen bonds were observed, forming chains along the c axis.
Conclusions:
- The observed anti-conformation influences the molecule's packing in the solid state.
- Hydrogen bonding plays a significant role in the self-assembly of this compound into crystalline chains.
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