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Related Concept Videos

Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
Acidity of 1-Alkynes02:42

Acidity of 1-Alkynes


The acidic strength of hydrocarbons follows the order: Alkynes > Alkenes > Alkanes. The strength of an acid is commonly expressed in units of pKa — the lower the pKa, the stronger the acid. Among the hydrocarbons, terminal alkynes have lower pKa values and are, therefore, more acidic. For example, the pKa values for ethane, ethene, and acetylene are 51, 44, and 25, respectively, as shown here.

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Related Experiment Video

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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

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Published on: January 19, 2016

Methyl 2-(benzene-sulfonamido)acetate.

Muhammad Nadeem Arshad, Islam Ullah Khan, Muhammad Zia-Ur-Rehman

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    The crystal structure of a novel benzothiazine precursor (C9H11NO4S) was determined. This compound

    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Medicinal Chemistry

    Background:

    • Benzothiazines are a class of heterocyclic compounds with diverse biological activities.
    • Identifying novel precursors is crucial for synthesizing new benzothiazine derivatives.

    Purpose of the Study:

    • To determine the crystal structure of the title compound, C9H11NO4S.
    • To understand the structural features that may relate to its precursor role in benzothiazine synthesis.

    Main Methods:

    • Single-crystal X-ray diffraction analysis was employed to elucidate the molecular and crystal structure.
    • Analysis of intermolecular interactions, including hydrogen bonding and C-H⋯O interactions.

    Main Results:

    • The crystal structure of C9H11NO4S was successfully determined.

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    Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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  • The crystal lattice is stabilized by significant intermolecular N-H⋯O and C-H⋯O interactions.
  • These interactions provide insights into the compound's solid-state packing and potential reactivity.

    • Conclusions:

    • The determined crystal structure confirms the compound's suitability as a precursor for biologically active benzothiazines.
    • The identified intermolecular interactions are key to the compound's structural stability and may influence its synthetic utility.