Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
IUPAC Nomenclature of Aldehydes01:16

IUPAC Nomenclature of Aldehydes

Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic carbon’s locant...
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids01:19

Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme activation, sulfur...
Carboxylic Acid Derivatives: Overview01:15

Carboxylic Acid Derivatives: Overview

Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
Amines to Sulfonamides: The Hinsberg Test01:23

Amines to Sulfonamides: The Hinsberg Test

The Hinsberg test is a method to identify primary, secondary and tertiary amines, named after its pioneer, Oscar Hinsberg. Here, amines are treated with benzenesulfonyl chloride, also known as the Hinsberg reagent, in the presence of an excess of aqueous base, followed by acidification. Based on the nature of the amines, different changes are observed.
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interfacial Control in Cu-MXene Hybrids Enables Selective NOx-to-NH<sub>3</sub> Electroconversion: A Critical Review.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Enhancing physio-biochemical characteristics in okra genotypes through seed priming with biogenic zinc oxide nanoparticles synthesized from halophytic plant extracts.

Scientific reports·2024
Same author

Fabrication and Investigation of Deformable Rubber-Carbon Nanotube-Glue Gel-Based Impedimetric and Capacitive Tactile Sensors for Pressure and Displacement Measurements.

Gels (Basel, Switzerland)·2024
Same author

Synthesis, structure elucidation, SC-XRD/DFT, molecular modelling simulations and DNA binding studies of 3,5-diphenyl-4,5-dihydro-1<i>H</i>-pyrazole chalcones.

Journal of biomolecular structure & dynamics·2023
Same author

Progress in layered double hydroxides (LDHs): Synthesis and application in adsorption, catalysis and photoreduction.

The Science of the total environment·2023
Same author

Redox mediators boost NO<sub>x</sub> reduction via trade-off electron charges using a cube-shaped (cMn@rGO) catalyst; mechanism and electrochemical study.

Chemosphere·2023

Related Experiment Video

Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
11:01

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

2-benzenesulfonamidobenzoic Acid.

Abdullah Mohamed Asiri, Mehmet Akkurt, Salman A Khan

    Acta Crystallographica. Section E, Structure Reports Online
    |May 18, 2011
    PubMed
    Summary

    This study details the molecular structure of a novel compound, C(13)H(11)NO(4)S. Analysis reveals specific dihedral angles and intra-molecular hydrogen bonding, crucial for understanding its crystal packing and properties.

    More Related Videos

    A Strategy for Sensitive, Large Scale Quantitative Metabolomics
    14:18

    A Strategy for Sensitive, Large Scale Quantitative Metabolomics

    Published on: May 27, 2014

    In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
    05:47

    In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

    Published on: August 28, 2019

    Related Experiment Videos

    Last Updated: Jun 1, 2026

    Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
    11:01

    Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

    Published on: November 23, 2016

    A Strategy for Sensitive, Large Scale Quantitative Metabolomics
    14:18

    A Strategy for Sensitive, Large Scale Quantitative Metabolomics

    Published on: May 27, 2014

    In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
    05:47

    In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

    Published on: August 28, 2019

    Area of Science:

    • Crystallography
    • Molecular Structure Analysis
    • Supramolecular Chemistry

    Background:

    • Understanding the three-dimensional arrangement of atoms in molecules is fundamental to predicting chemical and physical properties.
    • Hydrogen bonding plays a critical role in both molecular conformation and crystal lattice formation.
    • The study of organic compounds with sulfur and nitrogen heteroatoms is important for materials science and medicinal chemistry.

    Purpose of the Study:

    • To elucidate the detailed molecular structure of the title compound, C(13)H(11)NO(4)S.
    • To investigate the intra-molecular interactions and their influence on the overall molecular geometry.
    • To characterize the intermolecular forces governing the crystal packing.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the precise atomic coordinates and bond parameters.
    • Analysis of the crystal structure included the identification of hydrogen bonding networks and other non-covalent interactions.
    • Geometric parameters, such as dihedral angles, were calculated to describe the molecular conformation.

    Main Results:

    • The dihedral angle between the benzene ring and the carboxyl group was determined to be 13.7(1)°.
    • Intra-molecular hydrogen bonds (N-H⋯O and C-H⋯O) were identified within the molecule.
    • Crystal packing is stabilized by intermolecular C-H⋯O hydrogen bonds, O-H⋯O hydrogen bonds forming cyclic dimers (R(2)(2)(8)), and C-H⋯π interactions.

    Conclusions:

    • The molecular structure of C(13)H(11)NO(4)S is characterized by a specific dihedral angle and significant intra-molecular hydrogen bonding.
    • Intermolecular interactions, particularly O-H⋯O hydrogen bonds forming dimers, dictate the observed crystal packing.
    • These findings contribute to the understanding of structure-property relationships in organic crystalline materials.