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Updated: Jun 1, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
5-Dimethyl-amino-N,N-dimethyl-2-nitro-benzamide
Summary
This study details the crystal structure of a benzamide compound, C(11)H(15)N(3)O(3). Molecular analysis reveals a slight twist in a methyl group and stabilization through weak intermolecular interactions.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure Analysis
Background:
- Benzamide derivatives are important in medicinal chemistry.
- Understanding molecular conformation is crucial for drug design.
- Crystal packing influences material properties.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(11)H(15)N(3)O(3).
- To analyze the molecular geometry and intermolecular interactions.
- To provide insights into the solid-state behavior of this benzamide derivative.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and torsion angles.
- Identification and characterization of intermolecular interactions, including hydrogen bonds and C-H⋯π interactions.
Main Results:
- The crystal structure of C(11)H(15)N(3)O(3) was successfully determined.
- A specific methyl group on the benzamide unit exhibits a torsion angle of 4.04(13)°, indicating a slight twist.
- Crystal packing is stabilized by weak intermolecular C-H⋯O hydrogen bonds and C-H⋯π interactions.
Conclusions:
- The study provides a detailed structural characterization of the title benzamide compound.
- The observed molecular conformation and intermolecular forces dictate the crystal packing.
- These findings contribute to the understanding of structure-property relationships in benzamide derivatives.
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