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Updated: Jun 1, 2026
09:45
Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
N'-(2-Hydr-oxy-3,5-diiodo-benzyl-idene)-2-methoxy-benzohydrazide
Summary
Researchers synthesized a novel compound, C(15)H(12)I(2)N(2)O(3), via condensation. Structural analysis revealed two unique molecules with distinct dihedral angles and intramolecular hydrogen bonds, indicating complex crystal formation.
Area of Science:
- Organic Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- Salicylaldehyde derivatives and benzohydrazides are key building blocks in organic synthesis.
- Understanding molecular structure and intermolecular interactions is crucial for materials science.
Purpose of the Study:
- To synthesize and characterize a novel organic compound with the formula C(15)H(12)I(2)N(2)O(3).
- To investigate the crystal structure, including molecular conformation and hydrogen bonding patterns.
Main Methods:
- Chemical synthesis via condensation reaction of 3,5-diiodo-salicylaldehyde and 2-methoxy-benzohydrazide.
- Single-crystal X-ray diffraction to determine the crystal structure and molecular geometry.
Main Results:
- Successful synthesis of the target compound C(15)H(12)I(2)N(2)O(3).
- Identification of two independent molecules (A and B) in the asymmetric unit with varying dihedral angles (30.2(2)° and 21.7(2)°).
- Observation of intramolecular O-H⋯N and N-H⋯O hydrogen bonds within each molecule. The crystal exists as an inversion twin.
Conclusions:
- The synthesized compound exhibits distinct molecular conformations in the solid state.
- Intramolecular hydrogen bonding plays a significant role in stabilizing the molecular structures.
- The crystal packing is influenced by the presence of two independent molecules and inversion twinning.
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