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Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.

Carbocations

Carbocations

Carbocations are one of the reaction intermediates formed during several nucleophilic substitutions or elimination reactions. A carbocation is an electron-deficient species with the central carbon atom having six electrons and three bonded atoms. The central carbon in a carbocation is sp2 hybridized with trigonal planar geometry. It has an empty p orbital perpendicular to the plane of the structure that can accept electrons. Thus, carbocations act as strong electrophiles and may react with any...

Structures of Carboxylic Acid Derivatives

Structures of Carboxylic Acid Derivatives

Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...

IUPAC Nomenclature of Carboxylic Acids

IUPAC Nomenclature of Carboxylic Acids

IUPAC names of carboxylic acids are systematically derived following a few rules discussed below.
For acyclic saturated monocarboxylic acids, the longest hydrocarbon chain containing the –COOH carbon is identified as the parent chain. Then, the last -e of the parent hydrocarbon name is replaced with a suffix -oic acid.

Carboxylic Acid Derivatives: Overview

Carboxylic Acid Derivatives: Overview

Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:

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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

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Published on: November 23, 2016

Methyl 9H-carbazole-9-acetate.

Yong-Jun He¹, Min-Hao Xie, Pei Zou

¹Jiangsu Institute of Nuclear Medicine, Wuxi 214063, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|May 18, 2011

Summary

This summary is machine-generated.

Researchers synthesized a novel carbazole derivative, C(15)H(13)NO(2), via N-alkylation. The study details its planar carbazole structure and weak intermolecular hydrogen bonding in the crystal form.

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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)

Published on: June 20, 2014

Area of Science:

Organic Chemistry
Crystallography

Background:

Carbazole derivatives are important scaffolds in medicinal chemistry and materials science.
Understanding the structural and electronic properties of novel carbazole compounds is crucial for their application.

Purpose of the Study:

To synthesize and characterize a new carbazole derivative, C(15)H(13)NO(2).
To elucidate the crystal structure and intermolecular interactions of the synthesized compound.

Main Methods:

N-alkylation reaction between methyl bromoacetate and 9H-carbazole.
Single-crystal X-ray diffraction analysis to determine the molecular and crystal structure.

Main Results:

Successful synthesis of the target compound C(15)H(13)NO(2).
The carbazole ring system was found to be nearly planar.
A significant dihedral angle of 86.5° was observed between the carbazole moiety and the methyl acetate group.
Evidence of weak intermolecular C-H⋯O hydrogen bonding was identified in the crystal lattice.

Conclusions:

The study successfully synthesized a novel carbazole derivative.
The crystal structure reveals a near-planar carbazole core and specific spatial arrangement of the methyl acetate group.
The presence of weak C-H⋯O hydrogen bonds influences the crystal packing and stability.