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Updated: Jun 1, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2-[(4-Chloro-phen-yl)imino-meth-yl]hydro-quinone
Summary
This study reveals the crystal structure of a C(13)H(10)ClNO(2) compound, highlighting its phenol-imine form and hydrogen bonding. The findings detail molecular arrangement and intermolecular interactions in the solid state.
Area of Science:
- Crystallography
- Organic Chemistry
- Solid-State Chemistry
Background:
- Understanding the solid-state behavior of organic compounds is crucial for predicting their physical and chemical properties.
- Crystal structure analysis provides fundamental insights into molecular interactions and conformation.
Purpose of the Study:
- To determine the crystal structure of the title compound, C(13)H(10)ClNO(2).
- To investigate the molecular conformation and intermolecular interactions in the crystalline state.
Main Methods:
- Single-crystal X-ray diffraction was employed to elucidate the crystal structure.
- Analysis of bond lengths, bond angles, and intermolecular contacts was performed.
Main Results:
- The compound exists in the phenol-imine tautomeric form in the crystal.
- Aromatic rings exhibit a dihedral angle of 2.82(9)°.
- An intramolecular O-H⋯N hydrogen bond forms a planar six-membered ring.
- Intermolecular O-H⋯O hydrogen bonds link molecules into chains.
Conclusions:
- The crystal structure is stabilized by both intramolecular and intermolecular hydrogen bonding.
- The observed conformation and hydrogen bonding network dictate the packing in the solid state.
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