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A turn-on chemosensor for Hg2+ in aqueous media and its application in "MCT" imaging in living cells
Pinxian Xi1, Liang Huang, Guoqiang Xie
1Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Abstract:
A turn-on chemosensor L1, which exhibits high selectivity and sensitivity toward Hg(2+) over other common metal ions in aqueous media under a physiological pH window via a 1:1 binding mode, had been synthesized and characterized. L1 provides good fluorescent imaging of Hg(2+) in living cells. Particularly, we adopted the "micro computed tomography (MCT)" technology, successfully demonstrating the method of Hg(2+) sensing by L1 in cell lines, also the cell permeability of L1 and its imaging position in the cells.
