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Updated: Jun 1, 2026
Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
Published on: December 1, 2023
[Resistive training reduces inflammation in skeletal muscle and improves the peripheral insulin sensitivity in obese
Ana Carolina Panveloski-Costa1, Danilo Antônio Correa Pinto Júnior, Bruna Brasil Brandão
1Departamento de Fisioterapia, Universidade Estadual Paulista Júlio de Mesquita Filho, Presidente Prudente, SP, Brasil.
Objective:
To determine if resistive exercise protocol can modulate Tnf-α, SOCS3 and glucose transporter GLUT4 genes expression in skeletal muscle, and peripheral insulin sensitivity in obese rats induced by hyperlipidic diet.
Materials And Methods:
Wistar obese rats induced by hyperlipidic diet were subjected a resistive exercise protocol as jump squat. Insulin sensitivity and mRNA content of Tnf-α, SOCS3 and GLUT4 were assayed and compared among the groups: obese sedentary (OS) and exercised (OE), control sedentary (CS) and exercised (CE).
Results:
The mRNA content of Tnf-α and SOCS3 has increased in skeletal muscle from OS and has decreased in OE group. The protein and GLUT4 mRNA contents were correlated but they did not change among the groups. Peripheral insulin sensitivity has increased in the OE compared to OS group.
Conclusion:
The resistive exercise reverses the peripheral insulin resistance and the inflammatory state in skeletal muscle from diet-induced obese rats.
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