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Updated: Jun 1, 2026

Transplantation Into the Mouse Ovarian Fat Pad
Published on: September 7, 2016
Over-expression of cellular oncogenes in cystadenocarcinomas of the ovary
T Dingermann1, A Leipold, S Landgraf
1UNIV ERLANGEN NURNBERG,INST HUMANGENET,W-8520 ERLANGEN,GERMANY. UNIV ERLANGEN NURNBERG,FRAUENKLIN,W-8520 ERLANGEN,GERMANY.
Abstract:
A complex analysis of oncogene over-expression in ovarian cystadenocarcinomas of 20 patients was performed. Radioactively labelled cDNAs were synthesized from total cellular RNA from tumor cells and hybridized to dot blot filters. On each filter more than 20 different plasmids containing cloned oncogene fragments were immobilized. In concordance with published data fms was found over-expressed in 40% of the tumors. Elevated expression levels of the EGF receptor was also frequently detected. 35% of the tumors showed elevated N-ras mRNA levels. All those tumors' showed a highly dedifferentiated phenotype and were classified as G3-tumors. More over, simultaneous over-expression of different oncogenes correlated surprisingly strongly with tumor grading.
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