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Updated: Jun 1, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Preoperative radiotherapy for muscle-invading bladder-carcinoma
1BOWMAN GRAY SCH MED,DEPT RADIOL,MED CTR BLVD,WINSTON SALEM,NC 27157. BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,WINSTON SALEM,NC 27157. DUKE UNIV,MED CTR,DIV RADIAT ONCOL,DURHAM,NC 27710.
Abstract:
One hundred five patients with clinical stage T2-T4 transitional cell bladder carcinoma who completed either low-dose (20-26 Gy) or high dose (40-50 Gy) preoperative radiotherapy (RT) followed by cystectomy were reviewed. Five-year actuarial survival was 42%, 52%, and 17% for stages T2, T3, and T4, respectively. Five-year local control rates for stages T2, T3, and T4 was 93%, 93% and 22%, respectively. Survival, local control, distant metastasis and complications were similar for both preoperative regimens. The high rates of local control support the use of preoperative RT in selected patients with bladder carcinoma.
