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Related Experiment Videos

[Glyceryl nitrates may cause hypertension].

Peter Mørup¹, Tine Holbæk Levinsen, Peter Hovind

¹Klinisk, Fysiologisk og Nuklearmedicinsk Afdeling, Glostrup Hospital, 2600 Glostrup, Denmark. peter@moerup.org

Ugeskrift for Laeger

|May 19, 2011

Summary

An 82-year-old woman experienced paradoxical hypertension after receiving glyceryl trinitrate during a tilt table test. This rare response may be linked to cerebral blood flow autoregulation issues.

Area of Science:

Cardiology
Neurology

Background:

Orthostatism is a condition characterized by a drop in blood pressure upon standing.
Glyceryl trinitrate (nitroglycerin) is commonly used to treat chest pain and manage blood pressure.

Observation:

An 82-year-old female patient with orthostatism received a standard dose of glyceryl trinitrate during a tilt table test.
Ten minutes post-administration, she exhibited a paradoxical hypertensive response, with blood pressure rising to 205/111 mmHg.

Findings:

The patient's response was identified as paradoxical hypertension, potentially triggered by glyceryl trinitrate, orthostatism, and carotid artery massage.
This represents the third documented case of paradoxical hypertension induced by glyceryl trinitrate.

Implications:

Related Experiment Videos

The findings suggest that impaired cerebral blood flow autoregulation might be a contributing factor to this rare glyceryl trinitrate-induced hypertension.
Further research is warranted to understand the mechanisms behind paradoxical responses to vasodilators.