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Updated: Jun 1, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N'-(2-Meth-oxy-benzyl-idene)aceto-hydrazide.
1Linjiang College, Hangzhou Vocational and Technical College, Hangzhou 310018, People's Republic of China.
Summary
This study details the molecular structure of C(10)H(12)N(2)O(2), revealing a nearly planar acetohydrazide group and a trans configuration around the C=N bond. Crystal analysis shows molecules forming dimers via hydrogen bonds, stabilizing the overall structure.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure Analysis
Background:
- Understanding the precise three-dimensional arrangement of atoms in organic molecules is crucial for predicting their properties and reactivity.
- Acetohydrazide derivatives are common motifs in medicinal chemistry and materials science.
Purpose of the Study:
- To elucidate the detailed molecular geometry and crystal packing of the title compound, C(10)H(12)N(2)O(2).
- To investigate intermolecular interactions that stabilize the crystal structure.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular structure.
- Analysis of bond lengths, bond angles, dihedral angles, and torsion angles.
- Identification and analysis of hydrogen bonding and other intermolecular interactions.
Main Results:
- The acetohydrazide group was found to be nearly planar, with a dihedral angle of 12.15° relative to the benzene ring.
- A trans configuration was observed around the C=N bond.
- Centrosymmetric dimers formed by N-H⋯O hydrogen bonds and stabilized by C-H⋯O interactions were identified in the crystal lattice.
Conclusions:
- The study provides a precise structural characterization of C(10)H(12)N(2)O(2).
- The observed molecular conformation and crystal packing are dictated by specific hydrogen bonding and van der Waals interactions.
- This detailed structural information can serve as a basis for further studies on related compounds.
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