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Updated: Jun 1, 2026
![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)
Published on: June 28, 2011
N-(4-Methyl-benzo-yl)benzene-sulfonamide
This study details the molecular conformation of a novel compound, C(14)H(13)NO(3)S. Key findings reveal the anti-conformation of the N-H bond and specific dihedral angles between its aromatic rings.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure Analysis
Background:
- Understanding molecular conformation is crucial for predicting chemical properties and reactivity.
- The specific arrangement of atoms within a molecule influences its physical and biological behavior.
Purpose of the Study:
- To elucidate the precise three-dimensional structure and conformation of the title compound, C(14)H(13)NO(3)S.
- To analyze the spatial relationship between the sulfonyl group, amide linkage, and aromatic rings.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular structure.
- Analysis of bond lengths, bond angles, and dihedral angles provided conformational insights.
Main Results:
- The N-H bond within the C-SO(2)-NH-C(O) segment adopts an anti conformation relative to the C=O bond.
- The dihedral angle between the sulfonyl benzene ring and the S-N-C-O segment is 77.1(1)°.
- The dihedral angle between the sulfonyl and benzoyl benzene rings is 71.9(1)°.
Conclusions:
- The determined conformation provides a structural basis for understanding the compound's chemical characteristics.
- These findings contribute to the broader knowledge of sulfonamide and amide derivatives' structural diversity.
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