Related Experiment Video
Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
(E)-4-Bromo-N-(2,3,4-trimeth-oxy-benzyl-idene)aniline
This study details the E configuration of a Schiff base compound, C(16)H(16)BrNO(3). Researchers determined the specific dihedral angle between its aromatic rings, providing key structural insights.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Schiff base compounds are versatile organic molecules with diverse applications.
- Understanding the precise three-dimensional structure of these compounds is crucial for predicting their properties and reactivity.
Purpose of the Study:
- To elucidate the specific stereochemistry and conformation of the Schiff base compound C(16)H(16)BrNO(3).
- To provide detailed structural data for the title compound.
Main Methods:
- Single-crystal X-ray diffraction analysis was employed to determine the molecular structure.
- The configuration around the C=N bond and the dihedral angle between aromatic rings were analyzed.
Main Results:
- The Schiff base compound C(16)H(16)BrNO(3) was confirmed to adopt an E configuration about the C=N imine bond.
- The dihedral angle between the two aromatic rings was precisely measured as 64.02(6)°.
Conclusions:
- The study provides definitive structural confirmation of the E-isomer of the Schiff base.
- The determined dihedral angle offers valuable information for computational modeling and structure-activity relationship studies.
More Related Videos
09:46Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
Related Concept Videos
Nomenclature of Aryl and Heterocyclic Amines
Diazonium Group Substitution: –OH and –H
Nomenclature of Primary Amines
Physical Properties of Amines
NMR Spectroscopy of Benzene Derivatives
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3