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Induction of normal ultrastructure by CGRP treatment in dysgenic myotubes
L Garcia1, M Pinçon-Raymond, G Romey
1Groupe de Biologie et Pathologie neuromusculaires, U.153 INSERM, Paris, France.
FEBS Letters
|April 9, 1990
Abstract:
The calcitonin gene-related peptide (CGRP) restores an apparent normal ultrastructure in mdg/mdg muscle cells in vitro, including a normal triadic organization which is known to be essential for excitation-contraction (E-C) coupling. However, neither slow L-type Ca2+ channel activity nor E-C coupling, which are absent in mdg/mdg muscle, were re-established. These observations suggest a potential role of CGRP (and also of cAMP as the intracellular messenger) in the morphological development of the muscle fiber.