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Related Concept Videos

Newman Projections02:06

Newman Projections

Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
Nomenclature of Primary Amines01:17

Nomenclature of Primary Amines

Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.

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Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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Published on: July 28, 2022

N,N'-Bis(3-methyl-phen-yl)propane-diamide.

B Thimme Gowda, Miroslav Tokarčík, Vinola Z Rodrigues

    Acta Crystallographica. Section E, Structure Reports Online
    |May 19, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals the symmetrical molecular structure of C(17)H(18)N(2)O(2), stabilized by intramolecular hydrogen bonds. Molecules form chains in crystals via intermolecular hydrogen bonds and weak π-π stacking interactions.

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    An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

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    Area of Science:

    • Crystal engineering
    • Molecular structure determination
    • Organic chemistry

    Background:

    • Understanding molecular symmetry and intermolecular interactions is crucial for crystal engineering.
    • Hydrogen bonding and π-π stacking significantly influence crystal packing and material properties.

    Purpose of the Study:

    • To elucidate the precise molecular structure of the title compound, C(17)H(18)N(2)O(2).
    • To investigate the nature and role of intramolecular and intermolecular interactions in its crystal structure.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
    • Analysis of bond lengths, bond angles, and dihedral angles provided insights into molecular geometry.
    • Identification and analysis of hydrogen bonding and π-π stacking interactions.

    Main Results:

    • The molecular structure exhibits symmetry around a central carbon atom, with two halves related by a twofold rotation axis.
    • Intramolecular C-H⋯O hydrogen bonds stabilize each half of the molecule.
    • Intermolecular N-H⋯O hydrogen bonds link molecules into chains along the c-axis, further stabilized by π-π stacking.

    Conclusions:

    • The compound C(17)H(18)N(2)O(2) possesses a unique symmetrical structure with significant intramolecular stabilization.
    • Crystal packing is governed by a combination of strong intermolecular hydrogen bonds and weaker π-π stacking interactions.
    • These findings contribute to the understanding of structure-property relationships in organic crystalline materials.